2023-08-07
【學術亮點】比較兩品種雞接種傳染性支氣管炎病毒之免疫相關基因表現
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Intelligent Animal Husbandry: Development of intelligent and sustainable animal farming models with behavior indicators【Department of Animal Science / Chi-Feng Chen / Professor】
智慧牧場：應用行為指標建構智慧化永續生產飼養模式【動物科學系陳志峰教授】
智慧牧場：應用行為指標建構智慧化永續生產飼養模式【動物科學系陳志峰教授】
| 論文篇名 | 英文：Comparison of Immune-Related Gene Expression in Two Chicken Breeds Following Infectious Bronchitis Virus Vaccination 中文：比較兩品種雞接種傳染性支氣管炎病毒之免疫相關基因表現 |
| 期刊名稱 | Animals |
| 發表年份, 卷數, 起迄頁數 | 2023, 13(10), 1642 |
| 作者 | Chuwatthanakhajorn, Schwann; Chang, Chi=Sheng; Ganapathy, Kannan; Tang, Pin-Chi; Chen, Chi-Feng(陳志峰)* |
| DOI | 10.3390/ani13101642 |
| 中文摘要 | 本研究在鑑定台灣土雞和力康雞品種接種傳染性支氣管炎病毒疫苗後相關免疫基因及相應生物途徑。相較於力康雞，在接種疫苗後第14天和第21天，台灣土雞的抗傳染性支氣管炎病毒(IBV)抗體明顯上升；接種第7天，台灣土雞的MAPK 10、MHC-I、VPREB3的表現量增加。相較之外，力康雞的IL4I1、IL6、IL22RA2的表現量增加。這些研究凸顯出具有不同遺傳背景的雞之間免疫誘導的差異，並提供針對IBV減毒活疫苗免疫反應的生物途徑和特定基因。 |
| 英文摘要 | This study aims to identify the immune-related genes and the corresponding biological pathways following infectious bronchitis virus vaccination in Taiwan Country and White Leghorn chicken breeds. Transcriptomic analyses of the spleen of these two breeds were conducted by next-generation sequencing. Compared to White Leghorn chicken, Taiwan Country chicken showed a significantly higher level of anti-infectious bronchitis virus (IBV) antibodies at 14 and 21 days pos vaccination. At 7 days post vaccination, in the Taiwan Country chicken, higher expression of mitogen-activated protein kinase 10, Major histocompatibility complex class 1, and V-set pre-B cell surrogate light chain 3 were found. In contrast, the White Leghorn chicken had a high expression of interleukin 4 induced 1, interleukin 6, and interleukin 22 receptor subunit alpha 2. These findings have highlighted the variations in immune induction between chickens with distinct genetic background and provided biological pathways and specific genes involved in immune responses against live attenuated IBV vaccine. |
| 發表成果與AI計畫研究主題相關性 | AI演算協助家禽遺傳資訊分析 |
